Prostasin Is a Glycosylphosphatidylinositol-anchored Active Serine Protease
نویسندگان
چکیده
منابع مشابه
Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.
The membrane-anchored serine proteases prostasin (PRSS8) and matriptase (ST14) initiate a cell surface proteolytic pathway essential for epithelial function. Mice expressing only catalytically inactive prostasin are viable, unlike prostasin null mice, indicating that at least some prostasin functions are non-proteolytic. Here we used knock-in mice expressing catalytically inactive prostasin (Pr...
متن کاملDelineation of proteolytic and non-proteolytic functions of membrane-anchored serine protease Prss8/prostasin
The membrane-anchored serine proteases prostasin and matriptase initiate a cell surface proteolytic pathway essential for epithelial function. Mice expressing only catalytically-inactive prostasin, unlike prostasin null mice, are viable, indicating that at least some of prostasin’s functions are non-proteolytic. Here we used knockin mice expressing catalytically-inactive prostasin (Prss8) to sh...
متن کاملRegulation of Adrenal Aldosterone Production by Serine Protease Prostasin
A serine protease prostasin has been demonstrated to have a pivotal role in the activation of the epithelial sodium channel. Systemic administration of adenovirus carrying human prostasin gene in rats resulted in an increase in plasma prostasin and aldosterone levels. However, the mechanism by which the elevation of prostasin levels in the systemic circulation stimulated the plasma aldosterone ...
متن کاملThe serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer
BACKGROUND Ovarian cancer (OVC) is the deadliest of all gynecologic cancers, primarily as a consequence of asymptomatic progression. The complex nature of OVC creates challenges for early detection, and there is a lack of specific and sensitive biomarkers suitable for screening and detecting early stage OVC. METHODS Potential OVC biomarkers were identified by bioinformatic analysis. Candidate...
متن کاملMembrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a devastating disease that remains refractory to current therapies. OBJECTIVES To characterize the expression and activity of the membrane-anchored serine protease matriptase in IPF in humans and unravel its potential role in human and experimental pulmonary fibrogenesis. METHODS Matriptase expression was assessed in tissue specimens from pat...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m011423200